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Christian Haass, Professor of Metabolic Biochemistry at LMU Munich and spokesperson for the DZNE Munich, is known for his groundbreaking research hinein Alzheimer's disease. His work focuses on the molecular and cellular mechanisms of this disease in order to gain fundamental insights into its development.
81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Professor. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor rein a physiologically häufig pathway and not necessarily in a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
The theoretical test must be passed within one year of registering for a driving licence; hinein this period you can take the test as often as you wish. After failing the test twice, however, you must observe a three-month waiting period. The respective fee for the test must be paid each time.
Der markante Hütte mit den drei hohen Türmen wurde aus massiven Sandsteinblöcken erbaut des weiteren besitzt eine dekorative Rosette zumal ein Giebeldach.
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions hier klicken and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved in brain development (such as myelination and cell differentiation) but also provided the Lager for several current therapeutic approaches.
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Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
In addition, you can use our „Learning to drive“ app to extend your knowledge – wherever and whenever you wish. With this mix of classroom study and app training you will be fully prepared for the theoretical test.
You are allowed to have 10 negativ points. You have failed the test if you get 11 or more negativ points. If you incorrectly answer two questions each with five negativ points, you have also failed the test hinein spite of not exceeding the maximum number of minus points; hinein Class B, questions with 5 points have a greater relevance in the theoretical test.
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